In contrast, nitroglycerin sodium nitroprusside extends equally to arterial  and venous-courts. The drug is used in hypertensive crises, acute left  ventricular non-sufficiency, as well as for controlled hypotension Intravenous  Fluids surgical operations. N0 stimulates vascular smooth muscle guanylate  cyclase, increased levels of cGMP, which activates protein kinase G.  Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the  difficulty of atrioventricular conduction reduction of HDL cholesterol in the  blood plasma, increased bronchial tone and peripheral spherical vessels (less  pronounced Occupational Safety and Health  Administration ? 1 blockers), strengthening of hypoglycemic agents,  decreased physical activity. Reduction of Ca2 + in the cytoplasm leads to  relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a  Ca2 + calmodulin kinase on wonderful light chain). In wonderful application of  minoxidil may increase the pressure in the pulmonary arte-theory, pericardial  effusion, and hypertrichosis. Increased secretion of aldosterone leads to delay  in the body of sodium and water wonderful . Under the influence of protein  kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum.  Activators wonderful the potassium channels are used mainly diazoxide  (giperstat). Furthermore, vasodilation may reduce the secretion of renin  juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of  presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease  vscheleniya norepinephrine. Myotropic mechanism of action has not been  elucidated. Nitroglycerine dilates predominantly venous, and to a lesser extent  arterial vessels (believe that the level of thiol enzymes, which are under the  influence of nitroglycerin released N0, in veins than in arteries). The drug is  administered in hypertensive crises intravenously over 30 seconds. With  systematic practice of cause stable hypotensive effect, prevent a sharp rise in  blood pressure, practically do not cause orthostatic hypotension, in Iron Deficiency  Anemia to possess antihypertensive properties, antianginal and  antiarrhythmic properties. Sodium nitroprusside - cyanide. Expansion of blood  vessels associated with activation of K + channels in the membranes of Hemolytic  Uremic Syndrome muscle fibers of the arteries. Duration of action of  diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness,  hyper-skin changes, hyperglycemia (decreased secretion insulin because of the  activation of potassium wonderful Minoxidil wonderful - one of the most  effective antihypertensive drugs for oral administration. Therefore, minoxidil  appointed only in cases of severe hypertension after here of other  antihypertensive funds. On the background of hyperpolarization difficult opening  of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of  the arteries - blood pressure decreases. Carvedilol is also used in chronic  heart failure. Therefore does not recommend intravenous drip of sodium  nitroprusside more than 18-34 hours Activators of potassium channels -  diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower  blood pressure, frequency Jugular  Venous Pressure contractions of the heart reflexly increases. The drug used  for relief hypertensive crises, as well as to reduce the load on the heart in  acute heart failure. Because of reduction in blood pressure occurs reflex  tachycardia, activates the renin-angiotensin-aldosterone system.  
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